Extended Definition: Ifosfamide
Ifosfamide
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Ifosfamide
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| Systematic (IUPAC) name |
3-(2-chloroethyl)-2
-[(2-chloroethyl)amino]tetrahydro
-2H-1,3,2-oxazaphosphorine 2-oxide |
| Identifiers |
| CAS number |
3778-73-2 |
| ATC code |
L01AA06 |
| PubChem |
3690 |
| DrugBank |
APRD00007 |
| Chemical data |
| Formula |
C7H15Cl2N2O2P |
| Mol. mass |
261.1 |
| Pharmacokinetic data |
| Bioavailability |
100% |
| Metabolism |
Hepatic |
| Half life |
60-80% in 72 hours |
| Excretion |
Renal |
| Therapeutic considerations |
| Pregnancy cat. |
?
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| Legal status |
?
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| Routes |
intravenously |
Ifosfamide (pronounced eye.fos'.fa.mide) (also marketed as Mitoxana and Ifex) is a nitrogen mustard alkylating agent used in the treatment of cancer. It is a white powder which, when prepared for use in chemotherapy becomes a clear, colorless fluid. The delivery is intravenous, and is given as a treatment for a variety of cancers, including:
- Testicular cancer
- Breast cancer
- Lymphoma (Non-Hodgkin)
- Soft tissue sarcoma
- Osteogenic sarcoma
- Lung cancer
- Cervical cancer
- Ovarian cancer
- Bone cancer
Ifosfamide is often used in conjunction with Mesna to avoid internal bleeding in the patient, in particular hemorrhagic cystitis.
External links
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Chemotherapeutic agents/Antineoplastic agents (L01) |
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Purine+pyrimidine/
Ribonucleotides/
Deoxyribonucleotides |
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Antimetabolites
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Folic acid: (Aminopterin, Methotrexate, Pemetrexed, Raltitrexed)
Purine: (Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine)
Pyrimidine: (Cytarabine, Decitabine, Fluorouracil/Capecitabine, Floxuridine, Gemcitabine, Sapacitabine)
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| DNA |
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Alkylating/alkylating-like
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Nitrogen mustards: (Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan, Bendamustine, Trofosfamide, Uramustine)
Nitrosoureas:(Carmustine, Fotemustine, Lomustine, Nimustine, Prednimustine, Ranimustine, Semustine, Streptozocin)
Platinum (alkylating-like): (Carboplatin, Cisplatin, Nedaplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin)
Alkyl sulfonates:(Busulfan, Mannosulfan, Treosulfan)
Hydrazines:(Procarbazine)
Triazenes:(Dacarbazine, Temozolomide)
Aziridines:( Carboquone, ThioTEPA, Triaziquone, Triethylenemelamine)
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Spindle poison/mitotic inhibitor
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Taxane: (Docetaxel, Larotaxel, Ortataxel, Paclitaxel, Tesetaxel). Vinca: (Vinblastine, Vincristine, Vinflunine, Vindesine, Vinorelbine), Ixabepilone
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Cytotoxic/antitumor antibiotics
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Anthracycline family: (Aclarubicin, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Amrubicin, Pirarubicin, Mitoxantrone, Pixantrone, Valrubicin, Zorubicin)
streptomyces (Actinomycin, Bleomycin, Mitomycin, Plicamycin) - Hydroxyurea
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Topoisomerase inhibitors
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Camptotheca: (Camptothecin, Topotecan, Irinotecan, Rubitecan, Belotecan), Podophyllum:(Etoposide, Teniposide)
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Other
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Altretamine, Amsacrine, Bexarotene, Estramustine, Irofulven, Trabectedin
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| Cellular |
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CI monoclonal antibodies
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Receptor tyrosine kinase (Cetuximab, Panitumumab, Trastuzumab) - CD20 (Rituximab, Tositumomab) - other (Alemtuzumab, Bevacizumab, Edrecolomab, Gemtuzumab)
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Tyrosine kinase inhibitors
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Axitinib, Bosutinib, Cediranib, Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Lestaurtinib, Nilotinib, Semaxanib, Sorafenib, Sunitinib, Vandetanib
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Cyclin-dependent kinase inhibitor
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Alvocidib, Seliciclib
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Other
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Fusion protein (Aflibercept), Denileukin diftitox
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| Other/ungrouped |
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Photosensitizers
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Aminolevulinic acid, Efaproxiral, Methyl aminolevulinate, Porfimer sodium, Temoporfin, Verteporfin
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Other
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retinoids (Alitretinoin, Tretinoin), Anagrelide, Arsenic trioxide, Asparaginase (Pegaspargase), Atrasentan, Bortezomib, Carmofur, Celecoxib, Demecolcine, Elesclomol, Elsamitrucin, Etoglucid, Lonidamine, Lucanthone, Masoprocol, Mitobronitol, Mitoguazone, Mitotane, Oblimersen, Omacetaxine, Sitimagene ceradenovec, Testolactone, Tiazofurine, Tipifarnib
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Source: adapted by the editor from Wikipedia, the free encyclopedia; from the article "Ifosfamide". Image Credit.
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