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Idoxuridine
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| Systematic (IUPAC) name |
| 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl) oxolan-2-yl]- 5-iodo-pyrimidine-2,4-dione |
| Identifiers |
| CAS number |
54-42-2 |
| ATC code |
D06BB01 J05AB02, S01AD01 |
| PubChem |
5905 |
| DrugBank |
APRD00504 |
| Chemical data |
| Formula |
C9H11IN2O5 |
| Mol. mass |
354.099 g/mol |
| Pharmacokinetic data |
| Bioavailability |
? |
| Metabolism |
? |
| Half life |
? |
| Excretion |
? |
| Therapeutic considerations |
| Pregnancy cat. |
?
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| Legal status |
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| Routes |
intravenously |
Idoxuridine is an anti-herpesvirus antiviral drug.
It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the iodine atom added to the uracil component blocks base pairing.
External links
- Seth A, Misra A, Umrigar D (2004). "Topical liposomal gel of idoxuridine for the treatment of herpes simplex: pharmaceutical and clinical implications.". Pharm Dev Technol 9 (3): 277–89. doi:10.1081/PDT-200031432. PMID 15458233.
- Otto S. "Radiopharmaceuticals (Strontium 89) and radiosensitizers (idoxuridine).". J Intraven Nurs 21 (6): 335–7. PMID 10392098.
- Fauth E, Zankl H (1999). "Comparison of spontaneous and idoxuridine-induced micronuclei by chromosome painting.". Mutat Res 440 (2): 147–56. PMID 10209337.
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Antibiotics and chemotherapeutics for dermatological use (D06) |
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| Antibiotics |
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Tetracycline and derivatives
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Demeclocycline - Chlortetracycline - Oxytetracycline - Tetracycline
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Other
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Amphenicol: Chloramphenicol
Aminoglycoside: Neomycin - Gentamicin - Amikacin
Quinolone: Nadifloxacin
Streptogramin: Virginiamycin
Rifamycin: Rifaximin
other: Fusidic acid - Bacitracin - Tyrothricin - Mupirocin |
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| Chemotherapeutics |
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Silver sulfadiazine - Sulfathiazole - Mafenide - Sulfamethizole - Sulfanilamide - Sulfamerazine
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Antivirals
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Idoxuridine - Tromantadine - Aciclovir - Podophyllotoxin - Inosine - Penciclovir - Lysozyme - Ibacitabine - Edoxudine - Imiquimod - Docosanol
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Other
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Metronidazole
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Antivirals, other than for HIV (primarily J05, also S01AD and D06BB) |
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| Anti-herpesvirus (DNA, I) |
purine analogue (guanine) (Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir) • Vidarabine
pyrimidine analogue (uridine) (Idoxuridine, Trifluridine) • Cidofovir
Docosanol • Fomivirsen • Foscarnet • Tromantadine
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| HPV/MC (DNA, I) |
Imiquimod • Podophyllotoxin
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| Hepatitis B (DNA, VII) |
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| Hepatitis C (RNA, IV) |
Pegylated interferon alpha • Ribavirin • Taribavirin† • Boceprevir†
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| Picornavirus (RNA, IV) |
Pleconaril†
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| Anti-influenza agents (RNA, V) |
Arbidol
adamantane derivatives/M2 inhibitors (Amantadine, Rimantadine)
neuraminidase inhibitors (Oseltamivir, Zanamivir, Peramivir †) |
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| HIV (Reverse, VI) |
See HIV pharm
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| Other antiviral agents |
general (Inosine, Interferon)
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†Undergoing clinical trials, not FDA approved.
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Source: adapted by the editor from Wikipedia, the free encyclopedia; from the article "Idoxuridine". Image Credit.
