Extended Definition: Idarubicin
Idarubicin
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Idarubicin
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| Systematic (IUPAC) name |
| 9-acetyl-7-( 4-amino-5-hydroxy-6-methyl- tetrahydropyran-2-yl) oxy-6,9, 11-trihydroxy- 7,8,9,10-tetrahydrotetracene-5,12-dione |
| Identifiers |
| CAS number |
58957-92-9 |
| ATC code |
L01DB06 |
| PubChem |
42890 |
| DrugBank |
APRD00126 |
| Chemical data |
| Formula |
C26H27NO9 |
| Mol. mass |
497.494 g/mol |
| Pharmacokinetic data |
| Bioavailability |
? |
| Protein binding |
97% |
| Metabolism |
? |
| Half life |
22 hours |
| Excretion |
? |
| Therapeutic considerations |
| Pregnancy cat. |
?
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| Legal status |
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| Routes |
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Idarubicin or 4-demethoxydaunorubicin is an anthracycline drug that is used in the treatment of cancer. It belongs to the family of drugs called antitumor antibiotics. FDA approved label can be found here. It is distributed under trade name Zavedos.
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Chemotherapeutic agents/Antineoplastic agents (L01) |
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Purine+pyrimidine/
Ribonucleotides/
Deoxyribonucleotides |
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Antimetabolites
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Folic acid: (Aminopterin, Methotrexate, Pemetrexed, Raltitrexed)
Purine: (Cladribine, Clofarabine, Fludarabine, Mercaptopurine, Pentostatin, Thioguanine)
Pyrimidine: (Cytarabine, Decitabine, Fluorouracil/Capecitabine, Floxuridine, Gemcitabine)
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| DNA |
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Alkylating/alkylating-like
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Nitrogen mustards: (Chlorambucil, Chlormethine, Cyclophosphamide, Ifosfamide, Melphalan, Bendamustine, Trofosfamide, Uramustine)
Nitrosoureas:(Carmustine, Fotemustine, Lomustine, Nimustine, Prednimustine, Ranimustine, Semustine, Streptozocin)
Platinum (alkylating-like): (Carboplatin, Cisplatin, Nedaplatin, Oxaliplatin, Triplatin tetranitrate, Satraplatin)
Alkyl sulfonates:(Busulfan, Mannosulfan, Treosulfan)
Hydrazines:(Procarbazine)
Triazenes:(Dacarbazine, Temozolomide)
Aziridines:( Carboquone, ThioTEPA, Triaziquone, Triethylenemelamine)
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Spindle poison/mitotic inhibitor
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Taxane: (Docetaxel, Larotaxel, Ortataxel, Paclitaxel, Tesetaxel). Vinca: (Vinblastine, Vincristine, Vinflunine, Vindesine, Vinorelbine), Ixabepilone
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Cytotoxic/antitumor antibiotics
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Anthracycline family: ( Aclarubicin, Daunorubicin, Doxorubicin, Epirubicin, Idarubicin, Amrubicin, Pyrarubicin, Mitoxantrone, Pixantrone, Valrubicin, Zorubicin)
streptomyces (Actinomycin, Bleomycin, Mitomycin, Plicamycin) - Hydroxyurea
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Topoisomerase inhibitors
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Camptotheca: (Camptothecin, Topotecan, Irinotecan, Rubitecan, Belotecan), Podophyllum:(Etoposide, Teniposide)
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Other
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Altretamine, Amsacrine, Bexarotene, Estramustine, Irofulven, Trabectedin
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| Cellular |
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CI monoclonal antibodies
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Receptor tyrosine kinase (Cetuximab, Panitumumab, Trastuzumab) - CD20 (Rituximab, Tositumomab) - other (Alemtuzumab, Bevacizumab, Edrecolomab, Gemtuzumab)
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Tyrosine kinase inhibitors
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Axitinib, Bosutinib, Cediranib, Dasatinib, Erlotinib, Gefitinib, Imatinib, Lapatinib, Lestaurtinib, Nilotinib, Semaxanib, Sorafenib, Sunitinib, Vandetanib
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Cyclin-dependent kinase inhibitor
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Alvocidib, Seliciclib
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Other
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Fusion protein (Aflibercept), Denileukin diftitox
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| Other/ungrouped |
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Photosensitizers
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Other
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retinoids (Alitretinoin, Tretinoin), Anagrelide, Arsenic trioxide, Asparaginase (Pegaspargase), Atrasentan, Bortezomib, Carmofur, Celecoxib, Demecolcine, Elesclomol, Elsamitrucin, Etoglucid, Hydroxycarbamide, Lonidamine, Lucanthone, Masoprocol, Mitobronitol, Mitoguazone, Mitotane, Oblimersen, Omacetaxine, Sitimagene ceradenovec, Testolactone, Tiazofurine, Tipifarnib
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Source: adapted by the editor from Wikipedia, the free encyclopedia; from the article "Idarubicin". Image Credit.
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