Webster's Online Dictionary
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Definition: HOMATROPINE

Part of Speech Definition
Noun 1. An alkaloid, prepared from atropine, and from other sources. It is chemically related to atropine, and is used for the same purpose.[Websters].

Source: Webster's Revised Unabridged Dictionary (1913)

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Date "Homatropine" was first used in popular English literature: sometime before 1914. (references)

Note: Homatropine \Ho*mat"ro*pine\, noun. [Homo- atropine.]. (references)


Extended Definition: HOMATROPINE

Homatropine

Homatropine
Systematic (IUPAC) name
(N,N-dimethyl-8-azoniabicyclo[3.2.1]oct-3-yl) 2-hydroxy-2-phenyl-acetate bromide
Identifiers
CAS number 80-49-9
ATC code A02BX03 S01FA05
PubChem 6646
DrugBank APRD01017
Chemical data
Formula C16H22BrNO3 
Mol. mass 356.26 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life  ?
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes  ?

Homatropine (Equipin, Isopto Homatropine) is an anticholinergic medication that inhibits muscarinic acetylcholine receptors and thus the parasympathetic nervous system. It is used in eye drops as a cycloplegic, to temporarily paralyze accommodation, and as a mydriatic, to dilate the pupil.

Homatropine is less potent than atropine and has a shorter duration of action. It is available as the hydrobromide or methylbromide salt.

Certain preparations of drugs such as hydrocodone are mixed with a small, sub-theraputic amount homatropine methylbromide to discourage intentional overdose. [1]

Homatropine is also given as an atropine substitute given to reverse the muscarinic and CNS effects associated with indirect cholinomimetic (anti-AChase) administration.

Side effects

  • Blurred vision
  • Sensitivity to light

Contraindications

  • Untreated glaucoma
  • Myasthenia gravis
  • Severe heart failure
  • Thyrotoxicosis
Ophthalmologicals: mydriatics and cycloplegics (S01F)
Anticholinergics/antimuscarinics
Atropine - Scopolamine - Methylscopolamine - Cyclopentolate - Homatropine - Tropicamide
Sympathomimetics
Phenylephrine - Ephedrine - Ibopamine

Source: adapted by the editor from Wikipedia, the free encyclopedia; from the article "Homatropine". Image Credit.
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Topics by Level of Interest: HOMATROPINE

Topics sorted by level of Interest Level (1=low, 600=high)     Topics sorted Alphabetically Level (1=low, 600=high)
Homatropine 9     Homatropine 9

Source: the editor, created by/for EVE to gauge likely levels of human interest in linguistically triggered topics (compiled across various sources, such as Wikipedia and specialty expression glosses).

Translations: HOMATROPINE

Language Translations (or nearest inflections or synonyms, in parentheses)
Deutsch Tropinmandelat (homatropine), Homatropin (homatropine, tropine mandelate). Additional references: Deutsch, Germany, Austria, homatropine. (volunteer & more translations)
Français homatropine (homatropine, tropine mandelate). Additional references: Français, France, Algeria, homatropine. (volunteer & more translations)
French homatropine (homatropine, tropine mandelate). Additional references: French, France, Algeria, homatropine. (volunteer & more translations)
German Tropinmandelat (homatropine), Homatropin (homatropine, tropine mandelate). Additional references: German, Germany, Austria, homatropine. (volunteer & more translations)
High German Tropinmandelat (homatropine), Homatropin (homatropine, tropine mandelate). Additional references: High German, Germany, Austria, homatropine. (volunteer & more translations)
Hochdeutsch Tropinmandelat (homatropine), Homatropin (homatropine, tropine mandelate). Additional references: Hochdeutsch, Germany, Austria, homatropine. (volunteer & more translations)
Spanish homatropina (homatropine). Additional references: Spanish, Spain, Mexico, homatropine. (volunteer & more translations)
Source: Eve, based on a combination of meta analysis and graph theory (for near and back translations). Top

Constructed Language Translations: HOMATROPINE

Language Translations for “homatropine” or closest synonym(s); back translations in parentheses.
Pig Latin omatropinehay (homatropine). Additional references: Pig Latin, homatropine. (volunteer)
Terran B homatropinel (homatropine). Additional references: Terran B, homatropine. (volunteer)
Source: compiled by the editor. Top