| Domain | Definition | ||
| Health | 1: Anterior midline brain, cranial, and facial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. Alobar prosencephaly is the most severe form and features anophthalmia; cyclopia; severe mental retardation; cleft lip; cleft palate; seizures; and microcephaly. Semilobar holoprosencepaly is characterized by hypotelorism, microphthalmia, coloboma, nasal malformations, and variable degrees of mental retardation. Lobar holoprosencephaly is associated with mild (or absent) facial malformations and intellectual abilities that range from mild mental retardation to normal. Holoprosencephlay is associated with chromosome abnormalities. (references) | 2: A birth defect where the forebrain does not separate properly into two halves during early fetal life. The disorder results in mild to severe brain malformation and is sometimes fatal. It may be caused by environmental or genetic factors. Holoprosencephaly affects between 1 in 5,000 and 1 in 10,000 live births. (references) | |
| Medicine | A disorder characterised by the failure of the prosencephalon-the forebrain of the embryo-to develop. Source: European Union. (references) | ||
Source: compiled by the editor from various references; see credits. | Top | ||
Topics by Level of Interest: HOLOPROSENCEPHALY | ||||
| Topics sorted by level of Interest | Level (1=low, 600=high) | Topics sorted Alphabetically | Level (1=low, 600=high) | |
| Holoprosencephaly | 15 | Holoprosencephaly | 15 | |
Source: the editor, created by/for EVE to gauge likely levels of human interest in linguistically triggered topics (compiled across various sources, such as Wikipedia and specialty expression glosses). | ||||
