| Webster's Online Dictionary |
| Expressions | Domain | Definition | |
| Heavy Chain Disease | Health | A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N- (amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes. (references) | |
Source: compiled by the editor from various references; see credits. | Top | ||
