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Specialty Definition: ETRETINATE

DomainDefinition
HealthAn oral retinoid used in the treatment of keratotic genodermatosis, lichen planus, and psoriasis. Beneficial effects have also been claimed in the prophylaxis of epithelial neoplasia. The compound may be teratogenic. (references)

Source: compiled by the editor from various references; see credits.

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Extended Definition: Etretinate

Etretinate

Etretinate
Systematic (IUPAC) name
ethyl 9-(4-methoxy-2,3,6-trimethyl-phenyl)- 3,7-dimethyl-nona- 2,4,6,8-tetraenoate
Identifiers
CAS number 54350-48-0
ATC code D05BB01
PubChem 3312
DrugBank APRD00966
Chemical data
Formula C23H30O3 
Mol. mass 354.483 g/mol
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 120 days
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes Oral

Etretinate (trade name Tigason) is a medication used to treat severe psoriasis. It was removed from the United States market in 1998 and the Canadian market in 1996, due to the high risk of birth defects.

Etretinate has been replaced by acitretin, a metabolite of etretinate.

Precautions

  • Etretinate is a teratogen, and may cause birth defects long after use. Therefore, etretinate should only be used if one is never to get pregnant.
  • Etretinate should be avoided in children, as it may interfere with growth of bone.

Side effects

Antipsoriatics (D05)
Topical: tars
Tar
Topical: antracens
Dithranol
Topical: psoralens
Trioxysalen - Methoxsalen
Topical: other
Fumaric acid - vitamin D (Calcipotriol, Calcitriol, Tacalcitol) - Tazarotene
Systemic: psoralens
Trioxysalen - Methoxsalen - Bergapten
Systemic: retinoids
Etretinate - Acitretin

Source: adapted by the editor from Wikipedia, the free encyclopedia; from the article "Etretinate". Image Credit.



Topics by Level of Interest: ETRETINATE

Topics sorted by level of InterestLevel (1=low, 600=high)   Topics sorted AlphabeticallyLevel (1=low, 600=high)
Etretinate9   Etretinate9

Source: the editor, created by/for EVE to gauge likely levels of human interest in linguistically triggered topics (compiled across various sources, such as Wikipedia and specialty expression glosses).

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