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Specialty Definition: ETHOXZOLAMIDE

DomainDefinition
HealthA carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia. (references)

Source: compiled by the editor from various references; see credits.

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Extended Definition: Ethoxzolamide

Ethoxzolamide

Ethoxzolamide
Systematic (IUPAC) name
6-ethoxybenzothiazole-2-sulfonamide
Identifiers
CAS number 452-35-7
ATC code  ?
PubChem 3295
DrugBank APRD00732
Chemical data
Formula C9H10N2O3S2 
Mol. mass 258.319 g/mol
Pharmacokinetic data
Bioavailability  ?
Protein binding ~89%
Metabolism  ?
Half life 2.5-5.5 hours
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?
Legal status
Routes  ?

Ethoxzolamide (alternatively known as Ethoxyzolamide) is a sulfonamide medication that functions as a carbonic anhydrase inhibitor. It is used in the treatment of glaucoma, duodenal ulcers, and as a diuretic. It may also be used in the treatment of some forms of epilepsy.

Pharmacology

Ethoxzolamide, a sulfonamide, inhibits carbonic anhydrase activity in proximal renal tubules to decrease reabsorption of water, sodium, potassium, bicarbonate. It also decreases carbonic anhydrase in the CNS, increasing the seizure threshold. This reduction in carbonic anhydrase also reduces the intraocular pressure in the eye by decreasing aqueous humor.

Mechanism of Action

Ethoxzolamide binds and inhibits carbonic anhydrase I. Carbonic anhydrase plays an essential role in facilitating the transport of carbon dioxide and protons in the intracellular space, across biological membranes and in the layers of the extracellular space. The inhibition of this enzyme effects the balance of applicable membrane equilibrium systems.

Anticonvulsants (N03)
Barbiturates
Barbexaclone, Metharbital, Methylphenobarbital, Pentobarbital, Phenobarbital, Primidone
Hydantoins
Ethotoin, Fosphenytoin, Mephenytoin, Phenytoin
Oxazolidinediones
Ethadione, Paramethadione, Trimethadione
Succinimides
Ethosuximide, Mesuximide, Phensuximide
Benzodiazepines
Clobazam, Clonazepam, Clorazepate, Diazepam, Lorazepam, Midazolam, Nimetazepam, Nitrazepam, Temazepam
Carboxamides
Carbamazepine, Oxcarbazepine, Rufinamide
Fatty acid derivatives
Valpromide, Valnoctamide
Carboxylic acids
Valproic acid (Sodium valproate & Valproate semisodium), Tiagabine
Others
GABA analogs: Gabapentin, Pregabalin, Progabide, Vigabatrin -- Monosaccharides: Topiramate -- Aromatic allylic alcohols: Stiripentol -- Ureas: Phenacemide, Pheneturide -- Phenyltriazines: Lamotrigine

Carbamates: Emylcamate, Felbamate, Meprobamate -- Pyrrolidines: Brivaracetam, Levetiracetam, Nefiracetam, Seletracetam

Sulfa drugs: Acetazolamide, Ethoxzolamide, Sultiame, Zonisamide -- Propionates: Beclamide -- Aldehydes: Paraldehyde -- Bromides: Potassium bromide, Sodium bromide

Source: adapted by the editor from Wikipedia, the free encyclopedia; from the article "Ethoxzolamide". Image Credit.



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