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Specialty Expressions: EIF-2 KINASE

ExpressionsDomainDefinition
EIF-2 KinaseHealthA dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, eiF-2 kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of eIF-2, leading to the inhibition of protein synthesis. EC 2.7.10.-. (references)

Source: compiled by the editor from various references; see credits.

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Extended Definition: EIF-2 kinase

EIF-2 kinase

There are two mammalian eIF-2 alpha kinases, the double-stranded RNA-dependent kinase (PKR) and heme-regulated inhibitor kinase (HRI), both of which are responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized mechanisms for down-regulating protein synthesis in higher eukaryotes in response to various stress conditions.

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Source: adapted by the editor from Wikipedia, the free encyclopedia; from the article "EIF-2 kinase". Image Credit.