Dictionary - Definition of EIF-2

Specialty Definition: EIF-2

Domain	Definition
Health	Eukaryotic initiation factor of protein synthesis. The factor consists of three subunits, alpha, beta, and gamma. As initiation proceeds, eIF-2 forms a ternary complex with Met-tRNAi and GTP. (references)
Source: compiled by the editor from various references; see credits.		Top

Specialty Expressions: EIF-2

Expressions	Domain	Definition
EIF-2 Kinase	Health	A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, eiF-2 kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of eIF-2, leading to the inhibition of protein synthesis. EC 2.7.10.-. (references)
Source: compiled by the editor from various references; see credits.			Top

Extended Definition: EIF-2

eIF-2

eIF-2 (Eukaryotic Initiation Factor 2) is a heterotrimer of subunits alpha, beta, and gamma. eIF-2 mediates the binding of methionyl-tRNA_i^met to the ribosome in a GTP-dependent manner.

eIF-2 is released from the ribosome bound to GDP as an inactive binary complex.

To participate in another round of translation initiation, this GDP must be exchanged for GTP.

Under steady-state conditions of translation, eIF-2 must be recycled in order to participate in another round of translation initiation.

eIF-2B

Conversion of the inactive eIF-2-GDP to the active eIF-2-GTP form is catalyzed by a guanine nucleotide exchange factor, eIF-2B.

Phosphorylation of the alpha subunit of eIF-2 inhibits translation initiation by impairing the eIF-2B-catalyzed guanine nucleotide exchange reaction.

External links

MeSH EIF-2
Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors

translation --> Initiation factors:

Eukaryotic	eIF1 (eIF1A), eIF-2, eIF3, eIF4A, eIF4B, eIF4E, eIF4G, eIF4F, eIF5

GTP-binding protein regulators

GTPase activating protein	Chimerin 1 - RasGAP (Neurofibromin 1, IQ motif containing GTPase activating protein)

Guanine nucleotide exchange factor	EIF-2 - Son of Sevenless - Ras-GRF1

Other	Guanosine nucleotide dissociation inhibitors

Source: adapted by the editor from Wikipedia, the free encyclopedia; from the article "EIF-2". Image Credit.

Topics by Level of Interest: EIF-2
Topics sorted by level of Interest	Level (1=low, 600=high)	Topics sorted Alphabetically	Level (1=low, 600=high)
EIF-2	6	EIF-2	6
EIF-2 kinase	3	EIF-2 kinase	3
Source: the editor, created by/for EVE to gauge likely levels of human interest in linguistically triggered topics (compiled across various sources, such as Wikipedia and specialty expression glosses).

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