Webster's Online Dictionary
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Definition: Addison's disease

Part of SpeechDefinition
Noun1. A glandular disorder caused by failure of function of the cortex of the adrenal gland and marked by anemia and prostration with brownish skin.[Wordnet].
Expression1. A morbid condition causing a peculiar brownish discoloration of the skin, and thought, at one time, to be due to disease of the suprarenal capsules (two flat triangular bodies covering the upper part of the kidneys), but now known not to be dependent upon this causes exclusively. It is usually fatal.[Websters].

Sources: WordNet 3.0 Copyright © 2006 by Princeton University. All rights reserved. Webster's Revised Unabridged Dictionary (1913)

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Common Expressions: Addison's disease

ExpressionsDefinition
Addison's disease1: A morbid condition causing a peculiar brownish discoloration of the skin, and thought, at one time, to be due to disease of the suprarenal capsules (two flat triangular bodies covering the upper part of the kidneys), but now known not to be dependent upon this causes exclusively. It is usually fatal. Source: Webster's Revised Unabridged Dictionary.
 2: A glandular disorder caused by failure of function of the cortex of the adrenal gland and marked by anemia and prostration with brownish skin. Source: Wordnet 3.0 Copyright © 2006 by Princeton University. All rights reserved.
Addison's diseaseAddison's disease (also known as chronic adrenal insufficiency, or hypocortisolism) is a rare endocrine disorder, first described by British physician Thomas Addison. It is estimated that it affects about 1 to 2 in 100,000 people. It occurs when the adrenal glands, seated above the kidneys, fail to produce enough of the hormone cortisol and, sometimes, the hormone aldosterone. Addison's disease refers specifically to primary adrenal insufficiency, in which the adrenal glands themselves malfunction; secondary adrenal insufficiency occurs when the pituitary gland does not produce enough adrenocorticotropic hormone (ACTH) to adequately stimulate the adrenal glands. A famous sufferer of Addison's Disease was President John F. Kennedy. Jane Austen is thought to have been another. (references)

Source: compiled by the editor from various references; see credits.

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Specialty Expressions: Addison's disease

ExpressionsDomainDefinition
Addison's diseaseGeologyThis is a disease of the adrenal gland. The usual symptoms are weakness, easily feeling tired, loss of appetite, and sparse hair growth in some areas. Cortisol levels in the blood is low or absent. (references)
Addison's diseaseHealth1: A systemic disease, usually fatal, due to hypofunction of the cortical portion of the adrenal gland, characterized by bronzed pigmentation of the skin, general weakness, low blood pressure, severe anemia, and digestive disturbances. (references)
  2: A disease characterized by hypotension, weight loss, anorexia, weakness, and sometimes a bronze-like melanotic hyperpigmentation of the skin. It is due to tuberculosis- or autoimmune-induced disease (hypofunction) of the adrenal glands that results in deficiency of aldosterone and cortisol. In the absence of replacement therapy, it is usually fatal. (references)

Source: compiled by the editor from various references; see credits.

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