Adar
Adar can mean several things:
- Adar is a month of the Hebrew calendar
- Adar is the middle Persian term for Zoroastrian fire.
- Adar (Battlestar Galactica) is the name of two characters on Battlestar Galactica
- Richard Adar is the last president of the 12 Colonies before their destruction in the reimagined Battlestar Galactica
- President Adar is the last president of the 12 Colonies and killed on the Battlestar Atlantia at the Cylon Peace Conference in the original Battlestar Galactica.
- Adar is a creature in the Star Wars universe.
- Adar is a mountainous nation on the continent of Sarlona in the world of Eberron.
- Adar is also the plural of "aderyn" the word for bird in Cymraeg (Welsh).
- ADAR is an acronym for a type of Adenosine deaminase acting on RNA.
Source: adapted by the editor from Wikipedia, the free encyclopedia; from the article "Adar (disambiguation)". Image Credit.
Extended Definition: Adar
ADAR
|
Adenosine deaminase, RNA-specific | ||||||||||||||
| PDB rendering based on 1qbj. | ||||||||||||||
| Available structures: 1qbj, 1qgp, 1xmk, 2acj, 2gxb | ||||||||||||||
| Identifiers | ||||||||||||||
| Symbol(s) | ADAR; ADAR1; DRADA; DSH; DSRAD; G1P1; IFI-4; IFI4; K88dsRBP; p136 | |||||||||||||
| External IDs | OMIM: 601059 MGI: 1889575 Homologene: 9281 | |||||||||||||
| ||||||||||||||
| RNA expression pattern | ||||||||||||||
| Orthologs | ||||||||||||||
| Human | Mouse | |||||||||||||
| Entrez | 103 | 56417 | ||||||||||||
| Ensembl | ENSG00000160710 | ENSMUSG00000027951 | ||||||||||||
| Uniprot | P55265 | Q5J3Q8 | ||||||||||||
| Refseq | NM_001025107 (mRNA) NP_001020278 (protein) |
NM_001038587 (mRNA) NP_001033676 (protein) | ||||||||||||
| Location | Chr 1: 152.82 - 152.87 Mb | Chr 3: 89.8 - 89.84 Mb | ||||||||||||
| Pubmed search | [1] | [2] | ||||||||||||
Adenosine deaminase, RNA-specific, also known as ADAR, is a human gene.[1]
This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[1]
References
Further reading
- Valenzuela A, Blanco J, Callebaut C, et al. (1997). "HIV-1 envelope gp120 and viral particles block adenosine deaminase binding to human CD26.". Adv. Exp. Med. Biol. 421: 185-92. PMID 9330696.
- Wathelet MG, Szpirer J, Nols CB, et al. (1988). "Cloning and chromosomal location of human genes inducible by type I interferon.". Somat. Cell Mol. Genet. 14 (5): 415-26. PMID 3175763.
- Wang Y, Zeng Y, Murray JM, Nishikura K (1996). "Genomic organization and chromosomal location of the human dsRNA adenosine deaminase gene: the enzyme for glutamate-activated ion channel RNA editing.". J. Mol. Biol. 254 (2): 184-95. doi:10.1006/jmbi.1995.0610. PMID 7490742.
- Patterson JB, Samuel CE (1995). "Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase.". Mol. Cell. Biol. 15 (10): 5376-88. PMID 7565688.
- Patterson JB, Thomis DC, Hans SL, Samuel CE (1995). "Mechanism of interferon action: double-stranded RNA-specific adenosine deaminase from human cells is inducible by alpha and gamma interferons.". Virology 210 (2): 508-11. doi:10.1006/viro.1995.1370. PMID 7618288.
- O'Connell MA, Krause S, Higuchi M, et al. (1995). "Cloning of cDNAs encoding mammalian double-stranded RNA-specific adenosine deaminase.". Mol. Cell. Biol. 15 (3): 1389-97. PMID 7862132.
- Kim U, Wang Y, Sanford T, et al. (1994). "Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing.". Proc. Natl. Acad. Sci. U.S.A. 91 (24): 11457-61. PMID 7972084.
- Weier HU, George CX, Greulich KM, Samuel CE (1996). "The interferon-inducible, double-stranded RNA-specific adenosine deaminase gene (DSRAD) maps to human chromosome 1q21.1-21.2.". Genomics 30 (2): 372-5. doi:10.1006/geno.1995.0034. PMID 8586444.
- Liu Y, George CX, Patterson JB, Samuel CE (1997). "Functionally distinct double-stranded RNA-binding domains associated with alternative splice site variants of the interferon-inducible double-stranded RNA-specific adenosine deaminase.". J. Biol. Chem. 272 (7): 4419-28. PMID 9020165.
- Valenzuela A, Blanco J, Callebaut C, et al. (1997). "Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles.". J. Immunol. 158 (8): 3721-9. PMID 9103436.
- Herbert A, Alfken J, Kim YG, et al. (1997). "A Z-DNA binding domain present in the human editing enzyme, double-stranded RNA adenosine deaminase.". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8421-6. PMID 9237992.
- Liu Y, Herbert A, Rich A, Samuel CE (1998). "Double-stranded RNA-specific adenosine deaminase: nucleic acid binding properties.". Methods 15 (3): 199-205. doi:10.1006/meth.1998.0624. PMID 9735305.
- George CX, Samuel CE (1999). "Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible.". Proc. Natl. Acad. Sci. U.S.A. 96 (8): 4621-6. PMID 10200312.
- Schwartz T, Rould MA, Lowenhaupt K, et al. (1999). "Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA.". Science 284 (5421): 1841-5. PMID 10364558.
- Schade M, Turner CJ, Kühne R, et al. (1999). "The solution structure of the Zalpha domain of the human RNA editing enzyme ADAR1 reveals a prepositioned binding surface for Z-DNA.". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12465-70. PMID 10535945.
- Blanco J, Valenzuela A, Herrera C, et al. (2000). "The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression.". FEBS Lett. 477 (1-2): 123-8. PMID 10899322.
- Herrera C, Morimoto C, Blanco J, et al. (2001). "Comodulation of CXCR4 and CD26 in human lymphocytes.". J. Biol. Chem. 276 (22): 19532-9. doi:10.1074/jbc.M004586200. PMID 11278278.
- Wong SK, Sato S, Lazinski DW (2001). "Substrate recognition by ADAR1 and ADAR2.". RNA 7 (6): 846-58. PMID 11421361.
- Eckmann CR, Neunteufl A, Pfaffstetter L, Jantsch MF (2001). "The human but not the Xenopus RNA-editing enzyme ADAR1 has an atypical nuclear localization signal and displays the characteristics of a shuttling protein.". Mol. Biol. Cell 12 (7): 1911-24. PMID 11451992.
Source: adapted by the editor from Wikipedia, the free encyclopedia; from the article "ADAR". Image Credit.